Reduced Expression of the Survivin Gene in PBMC from Silicosis Patients
スポンサーリンク
概要
- 論文の詳細を見る
To explore the mechanism involved in immunological disorders associated with silicosis, the expression of IAP family genes in peripheral blood mononuclear cells from silicosis patients was examined. Relative gene expression was assayed using the multiplex RT-PCR for the XIAP and survivin genes. The correlation between those expression levels and various clinical parameters was then analyzed. The relative expression level of the survivin gene was reduced in silicosis patients as compared with that of healthy volunteers. The expression level of survivin positively correlated with PCO_2 values. These results support the existence of two populations of T lymphocytes in silicosis patients, one resistant to Fas-mediated apoptosis (a self-recognizing long-surviving fraction) and the other one sensitive to silica-induced apoptosis and repeatedly undergoing death and recruitment.
- 川崎医科大学の論文
著者
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UEKI Ayako
Department of Hygiene, Kawasaki Medical School
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OTSUKI Takemi
Department of Hygiene, Kawasaki Medical School
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Ueki A
Department Of Rehabilitation Faculty Of Health Science And Technology Kawasaki University Of Medical
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Ueki Ayako
川崎医科大学 衛生学教室
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Ueki Ayako
川崎医療福祉大学
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Hyodoh Fuminori
Department of Hygiene, Kawasaki Medical School
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SHIMIZU TOSHIYUKI
Department of Pediatrics, Yamagata University School of Medicine
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Otsuki T
Department Of Hygiene Kawasaki Medical School
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Otsuki Takemi
Department Of Hygiene Kawasaki Medical School
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Guo Zhong-qiu
Department Of Hygiene Kawasaki Medical School
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SAKAGUCHI Haruko
Department of Hygiene, Kawasaki Medical School
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Ueki A
Kawasaki University Of Medical Welfare
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Ueki Ayako
Department Of Hygiene
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Ueki Ayako
Department Of Anatomy Okayama University Medical School
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KUSAKA Masayasu
Department of Medicine, Kusaka Hospital, Japan
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KUSAKA Masayasu
Kusaka Hospital
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Hyodoh Fuminori
The First Department Of Nursing Kawasaki College Of Allied Health Professions
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Hyodoh Fuminori
Department Of Hygiene Kawasaki Medical School
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TOMOKUNI Akiko
Department of Hygiene, Kawasaki Medical School
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TACHIYAMA Shiho
Department of Applied Medical Engineering, Kawasaki College of Allied Health Professions
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Kusaka Masayasu
Department Of Medicine Kusaka Hospital Japan
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Kusaka Masayasu
Department Of Internal Medicine Kusaka Hospital
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Tachiyama Shiho
Department Of Applied Medical Engineering Kawasaki College Of Allied Health Professions
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Sakaguchi Haruko
Department Of Hygiene
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Takata Akiko
Department Of Hygiene Kawasaki Medical School
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Sakaguchi H
Department Of Hygiene
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Shimizu Toshiyuki
Department Of Applied Medical Engineering Kawasaki College Of Allied Health Professions
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Shimizu Toshiyuki
Department of Applied Chemistry, Faculty of Engineering, Osaka City University
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