Stimulation of Glucose Uptake in Muscle Cells by Prolonged Treatment with Scriptide, a Histone Deacetylase Inhibitor(Food & Nutrition Science)
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概要
- 論文の詳細を見る
Glucose incorporation is regulated mainly by GLUT4 in skeletal muscles. Here we report that treatment of L6 myotubes with scriptide, a hydroxamic acid-based histone deacetylase (HDAC) inhibitor, stimulated 2-deoxyglucose uptake. The effect appeared only after 24 hr, resulting in 2.4-fold glucose uptake at treatment day 6. Scriptide acted synergistically with insulin, indicating it stimulated a distinct pathway from the insulin signaling pathway. It was not observed in undifferentiated myoblasts or 3T3-L1 adipocytes, suggesting a muscle-specific effect of scriptide. A fivecarbon chain and hydroxamic acid, essential for histone deacetylase inhibition, were indispensable for this effect, and trichostatin A stimulated glucose uptake as well. Scriptide increased the cellular content of GLUT4, and induced GLUT4 translocation, but GLUT4 mRNA level did not change, indicating scriptide functions posttranslationally. Our results indicated a novel function for HDAC inhibitors of increasing GLUT4 content and its translocation in muscle cells, resulting in stimulation of glucose uptake.
- 社団法人日本農芸化学会の論文
- 2003-07-23
著者
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Murata Mitsuo
Medicinal Research Laboratories Taisho Pharmaceutical Co. Ltd.
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Nakagawa J
Dep. Of Food Sci. And Technol. Tokyo Univ. Of Agriculture
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TAKIGAWA-IMAMURA Hisako
Medicinal Research Laboratories, Taisho Pharmaceutical Co., Ltd.
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SEKINE Takumi
Medicinal Research Laboratories, Taisho Pharmaceutical Co., Ltd.
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TAKAYAMA Kiyoshi
Medicinal Research Laboratories, Taisho Pharmaceutical Co., Ltd.
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NAKAZAWA Kiyoshi
Medicinal Research Laboratories, Taisho Pharmaceutical Co., Ltd.
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NAKAGAWA Junichi
Medicinal Research Laboratories, Taisho Pharmaceutical Co., Ltd.
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Takayama Kiyoshi
Medicinal Research Laboratories Taisho Pharmaceutical Co. Ltd.
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Sekine Takumi
Medicinal Research Laboratories Taisho Pharmaceutical Co. Ltd.
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Nakagawa Junichi
Department Of Food Science And Technology Faculty Of Bioindustry Tokyo University Of Agriculture
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Takigawa-imamura Hisako
Medicinal Research Laboratories Taisho Pharmaceutical Co. Ltd.
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Nakazawa Kiyoshi
Medicinal Research Laboratories Taisho Pharmaceutical Co. Ltd.
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Nakagawa Junichi
Medicinal Research Laboratories Taisho Pharmaceutical Co. Ltd.
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