Bioconversion of 9-Monoacetyl-Josamycin to Josamycin by Streptomyces olivochromogenes

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概要

• 論文の詳細を見る

• Some species of Streptomyces including S. olivochromogenes var. abashirensis were forund to liberate 9-acetyl groups of artificial josamycin derivatives, such as 9-monoacetyl-josamycin and 9,2'-diacetyl-josamycin, but not to liberate 3-acetyl and 4"-isovaleryl groups of josamycin or its derivatives. 3-Deacetyl-josamycin which is a by-product in the josamycin fermentation is chemically converted to 9-monoacetyl-josamycin as well as josamycin. Therefore, this bioconversion of 9-monoacetyl-josamycin to josamycin as described here may enable 3-deacetyl-josamycin to be used as a useful resource for the manufacture of josamycin.

• 社団法人日本生物工学会の論文
• 1991-05-25

著者

• Osono T

  Central Research Laboratories

• EIKI HIDEO

  Yamanouchi Pharmaceutical CO., Ltd., Manufacturing Technology Institute

• YAMAGUCHI HIROSHI

  Central Research Laboratories

• SUZUKI KENICHI

  Central Research Laboratories

• SAITO TAKESHI

  Central Research Laboratories

• OSONO TAKASHI

  Central Research Laboratories

• Eiki H

  Yamanouchi Pharmaceutical Co. Ltd. Manufacturing Technology Institute

• Yamaguchi Hiroshi

  Central R&d Laboratory Kobayashi Pharmaceutical Co. Ltd.

関連論文

• Bioconversion of 9-Monoacetyl-Josamycin to Josamycin by Streptomyces olivochromogenes
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• Effect of Mineral Salts on Apparent Viscosity and a Ratio of Product Components in Josamycin Fermentation
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