Effect of Mineral Salts on Apparent Viscosity and a Ratio of Product Components in Josamycin Fermentation

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概要

• 論文の詳細を見る

• 3-O-Deacetyl-josamycin (DeAcJM) was accumulated as a by-product in josamycin fermentation by Streptomyces narbonensis var. josamyceticus. Josamycin accumulation was apparently related to the degree of mycelial growth and the accelerative increase in apparent viscosity of the broth. However, the oxygen transfer coefficient was reduced by an increase in the apparent viscosity and had a significant influence on josamycin formation. Josamycin accumulation was found to be inversely proportional to the DeAcJM-ratio. defined as the ratio of DeAcJM to the sum of josamycin and DeAcJM. Several ingredients of the medium and fermentation conditions were observed to alter the DeAcJM-ratio. In particular, the addition of mineral salts acted dramatically to reduce the apparent viscosity and DeAcJM-ratio. The reduction of the apparent viscosity causes improvement in the oxygen transfer coefficient. This brings about a considerable decrease in the DeAcJM-ratio along with a convergence in josamycin while increasing josamycin accumulation.

• 社団法人日本生物工学会の論文
• 1989-05-25

著者

• Osono T

  Central Research Laboratories

• EIKI HIDEO

  Yamanouchi Pharmaceutical CO., Ltd., Manufacturing Technology Institute

• SAITO TAKESHI

  Central Research Laboratories

• OSONO TAKASHI

  Central Research Laboratories

• GUSHIMA HIROSHI

  Central Research Laboratories

• EIKI HIDEO

  (Present address)Manufacturing Technology Institute, Yamanouchi Pharmaceutical Co., Ltd.,

• ISHIDA HITOSHI

  Central Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd.,

• OKA YOSHIHIKO

  Central Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd.,

• Eiki H

  Yamanouchi Pharmaceutical Co. Ltd. Manufacturing Technology Institute

• Oka Yoshihiko

  Central Research Laboratories Yamanouchi Pharmaceutical Co. Ltd.

• Ishida Hitoshi

  Central Research Laboratories Yamanouchi Pharmaceutical Co. Ltd.

• Gushima H

  Central Research Laboratories

関連論文

• Bioconversion of 9-Monoacetyl-Josamycin to Josamycin by Streptomyces olivochromogenes
• Effect of Broth Dilution and Its Application in Josamycin Fermentation
• Effect of Mineral Salts on Apparent Viscosity and a Ratio of Product Components in Josamycin Fermentation
• Product Inhibition and Its Removal on Josamycin Fermentation by Streptomyces narbonensis var. josamyceticus
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