Effect of Broth Dilution and Its Application in Josamycin Fermentation
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概要
- 論文の詳細を見る
Streptomyces narbonesis var. josamyceticus josamycin fermentation broth exhibited typical pseudo-plastic flow. The power requirement in a stirred vassel for the broth was approximately equal to that for the broth diluted with water by half or for water itself, except in a range of lower afitation speeds. However, the flow patterns were quite different. Dilution of the broth with water produced some advantages, such as a drastic reduction in the apparent viscosity of the broth and an improvement in the flow pattern. Josamycin yield was significantly affected by the degree of oxygen supply by various fixed agitation speeds. To improve oxygen supply and josamycin yield, periodic dilution with water successfully applied to josamycin fermentation.
- 社団法人日本生物工学会の論文
- 1990-08-25
著者
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Osono T
Central Research Laboratories
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EIKI HIDEO
Yamanouchi Pharmaceutical CO., Ltd., Manufacturing Technology Institute
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SAITO TAKESHI
Central Research Laboratories
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GUSHIMA HIROSHI
Central Research Laboratories
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OSONO TAKASI
Central Research Laboratories
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Eiki H
Yamanouchi Pharmaceutical Co. Ltd. Manufacturing Technology Institute
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Gushima H
Central Research Laboratories
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