Microbial Bioassay of Acute Toxicity by the pH Inhibition Method and Comparison of IC_<50> (pHI) with LD_<50> for Rats and Mice

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概要

• 論文の詳細を見る

• A bioassay of the toxicity of 12 test chemicals in described using Klebsiella pneumonia grown at 35℃ in a medium containing potassium citrate in which the pH increased steadily as the bacteria continued to grow. The chemicals tested were nine metallic ions, two alcohols, and phenol. The pH of the medium was recorded automatically every 3.6 h for 15 h. The 50% inhibitory concentrations (IC_<50>) of the test chemicals (mg/l) were 0.9 for Hg, 2.9 for Cd, 2.9 for Cr^<6->, 7.5 for Cu, 19,for Cr^<3-> 25 for Zn, 50 for CN, 91 for Mn, 1,430 for phenol, 53,300 for ethanol, and 74,200 for methanol. LD_<50> values for rats given the compoundsper os and for mice given them intraperitoneally were correlated with the IC_<50> values obtained by this method. The method might be used in preliminary screening for toxicity before tests in experimental animals.

• 公益社団法人日本生物工学会の論文
• 1993-11-25

著者

• Yoshikawa Kentaro

  Department Of Food And Nutrition Faculty Of Agriculture Kinki University

• ISHII RYUICHIRO

  Department of Food and Nutrition, Faculty of Agriculture, Kinki University

• Ishii R

  Department Of Food And Nutrition Faculty Of Agriculture Kinki University

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