Fermentation of Mevalonate by Saccharomycopsis fibuligera IFO 0107
スポンサーリンク
概要
- 論文の詳細を見る
Saccharomycopsis fibuligera IFO 0107 was found to overproduce R-mevalonate. In a typical experiment this strain produced 8.3 mg/ml of mevalonate. Mevalonate is synthesized by 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase and converted to 5-phosphomevalonate by mevalonate kinase. The yeast strain showed 3〜20 time higher HMG-CoA reductase and 〜4 times lower mevalonate kinase activities, as compared with several yeast strains which produced no detectable amounts of mevalonate. The high ratio of specific activity of HMG-CoA reductase/mevalonate kinase seems to be responsible for the accumulation of mevalonate by S. fibuligera IFO 0107.
- 社団法人日本生物工学会の論文
- 1989-07-25
著者
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endo akira
Department of Cardiology, Saitama Cardiovascular Respiratory Center
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Endo Akira
Department Of Cardiology Saitama Prefecture Cardiovascular And Respiratory Center
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遠藤 章
東京農工大学
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違藤 章
東京農工大・農・醗酵
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Koike Seiji
Department Of Agricultural And Biological Chemistry Tokyo Noko University
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MURAKAWA Shigeo
Department of Surgery , Osaka Medical College
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Murakawa S
Tokyo Noko Univ. Tokyo Jpn
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Murakawa Shigeo
Department Of Agricultural Chemistry Tokyo Noko University
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Endo Akira
Department Of Agricultural And Biological Chemistry Tokyo Noko University
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MURAKAWA SHIGEO
Department of Agricultural and Biological Chemistry, Tokyo Noko University
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