Antiproliferative Activity of Flavonoids on Several Cancer Cell Lines
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概要
- 論文の詳細を見る
Twenty-seven Citrus flavonoids were examined for their antiproliferative activities against several tumor and normal human cell lines. As a result, 7 flavonoids were judged to be active against the tumor cell lines, while they had weak antiproliferative activity against the normal human cell lines. The rank order of potency was luteolin, natsudaidain, quercetin, tangeretin, eriodictyol, nobiletin, and 3,3', 4', 5,6,7,8-heptamethoxyflavone. The structure-activity relationship established from comparison among these flavones and flavanones showed that the ortho-catechol moiety in ring B and a C2-C3 double bond were important for the antiproliferative activity. As to polymethoxylated flavones, C-3 hydroxyl and C-8 methoxyl groups were essential for high activity.
- 社団法人日本農芸化学会の論文
- 1999-05-23
著者
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YANO Masamichi
National Institute of Fruit Tree Science
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Ogawa Kazunori
National Institute Of Fruit Tree Science
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KAWAII Satoru
National Institute of Fruit Tree Science
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TOMONO Yasuhiko
National Institute of Fruit Tree Science
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KATASE Eriko
National Institute of Fruit Tree Science
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Tomono Y
National Institute Of Fruit Tree Science
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