Regulation of a Bule Pigment Production by γ-Nonalactone in Streptomyces sp.

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Physiological studies on staphylomycin production have indicated that in the culture of streptomyces virginiae, an unidentified inducer(IM), having a γ- or δ-lactone structure, is produced before production of the antibiotic and the inducer exhibits an action of induction as well as one of repression of staphylomycin production, depending on the culture age at addition. The action of IM are reproduced by a synthetic analog, γ-nonalactone.Since these regulatory phenomena are of interest in that they implicate cell differentiation in antibiotic production, efforts have been made to find similar phenomenon for other biosynthetic functions. Blue pigment formation by a cycloserine producer, Strepromyces sp. FRI 5,was induced by γ-nonalactone as well as IM. After establishing an assay method for the pigment formation, a cultivation study was performed to compare the behavior with that observed in staphylomycin production. The minimum concentration of γ-nonalactone required for inducing cells of 8-h age to produce pigment was 20 μg/ml. In the cultures with γ-nonalactone added at the early cultivation phase of 0-3 h, no pigment formation occurred, indicating a repressing action by the lactone. The maximum amount of the pigment in the culture increased as the time of γ-nonalactone addition was delayed until 8 h after inoculation and thereafter decreased. These results indicate that the inducing and repressing actions of the two lactones in the pigment production are analogous to those in staphylomycin production.
公益社団法人日本生物工学会の論文
1983-12-25

Regulation of a Bule Pigment Production by γ-Nonalactone in Streptomyces sp.

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