Optimal pH Profile in Rifamycin B Fermentation

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概要

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• A kinetic study on rifamycin B production in a batch culture of Nocardia mediterranei was undertaken in part of our endeavor to optimize the fermentation conditions.The growth kinetics in a batch culture was found to be successfully interpreted by logistic laws, i.e., the initial specific growth rate and the maximum cell mass concentration were determined as a function of pH and both found to have maxima. For the production of rifamycin B, non-growth associated production kinetics was employed and the yield coefficient as a function of pH was found to have one maximum point.The yield coefficient and the specific productivity were calculated as mean values in the idiophase. Utilizing these experimental data as a function of pH, the optimal conditions for rifamycin B production were discussed with regard to the pH effect on the cell growth and production of the antibiotic.As a result, the trophophase as pH 6.5 and the idiophase at pH 7.0 were found to be recommendable.

• 社団法人日本生物工学会の論文
• 1983-02-25

著者

• Lee J.

  Department of Biomedical Engineering, Kyungpook National University Hospital

• Han M.

  Biotechnology Research Department Korea Advanced Institute Of Science And Technology

• CHOI C.

  Department of Neurology, College of Medicine, Yonsei University

• Lee J.

  Department Of Chemical Technology College Of Engineering Seoul National University

• SEONG B.

  Biotechnology Research Department, Korea Advanced Institute of Science and Technology

• Lee J.

  Department Geosystem Engineering Kangwon National University

• Choi C.

  Department Of Chemical Technology College Of Engineering Seoul National University

• Seong B.

  Biotechnology Research Department Korea Advanced Institute Of Science And Technology

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