Degeneration of Herbicidin A-Producer, Streptomyces saganonensis, and Strain Improvement

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概要

• 論文の詳細を見る

• The degeneration of the nucleoside-antibiotic herbicidin A producing organism, Streptomyces saganonensis no. 4075,and its improvement were studied. 1) It was confirmed, by using a mixed culture of herbicidin-producing and non-producing strains, that the instability of herbicidin A production resulted from successive transfer of seed culture containing non-producing strains. 2) The growth rate of the non-producing strains was 1.4 times that of the producing strain. 3) Addition of 0.4 mg/ml of 9-β-D-arabinofuranosyl adenine (ara-A) selectively inhibited the growth of the non-producing strains. A high-producing strain was isolated on an agar plate containing ara-A (1.0 mg/ml).

• 社団法人日本生物工学会の論文
• 1982-10-25

著者

• YOSHIKAWA HIROJI

  Fermentation Research Laboratory, Sankyo Co. Ltd.,

• TAKIGUCHI YO

  (Present address)Fermentation Research Laboratories, Sankyo Co., Ltd.,

• TERAO MICHIYA

  Fermentation Research Laboratories, Sankyo Co., Ltd.,

• Yoshikawa Hiroji

  Fermentation Research Laboratories Sankyo Co. Ltd.

関連論文

• Fuzzy Control in Microbial Production of ML-236B, a Precursor of Pravastatin Sodium
• Morphology Control of Preculture during Production of ML-236B, a Precursor of Pravastrain Sodium, by Penicillium citrinum
• Production of ML-236B, and Inhibitor of 3-Hydroxy-3-methylglutaryl CoA Reductase, by Penicillium citrinum : Improvements of Strain and Culture Conditions
• Morphology Study in Production of ML-236B, a Precursor of Pravastatin Sodium, by Penicillium citrinum
• Conversion of Fermentation Pathway of Streptomyces saganonensis from Herbicidin A to Ara-A
• Degeneration of Herbicidin A-Producer, Streptomyces saganonensis, and Strain Improvement

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