Sulfazecin, a Novel β-Lactam Antibiotic of Bacterial Origin : Discovery, Fermentation and Biological Characterization

概要

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A novel β-lactam antibiotic, named sulfazecin, was found to be produced by a bacterium isolated from soil, strain G-6302. The bacterium was an oxidase-negative pseudomonad bearing a monotrichous flagellum, and was designated Pseudomonas acidophila on the basis of its acidophilic property. Sulfazecin was produced in parallel with bacterial growth in nutrient broth containing glycerol under aerated conditions. Organic and inorganic sulfur compounds increased the titre of sulfazecin. The antimicrobial activity of sulfazecin was characterized by its selective inhibition of Gramnegative bacteria and its stability to β-lactamases. Sulfazecin protected mice from an experimental infection by Escherichia coli.
社団法人日本生物工学会の論文
1981-08-25