Comparative Study of Methionine Effect on Cephalosporin Production by Various Fungi : Studies on the Production of β-Lactam Antibiotics (VIII)

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概要

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• Cephalosprium acremonium CMI 49137 (ATCC 11550), Brotzu's strain, was compared with 41 strains of the genera Cephalosporium, Emericellopsis, Paecilomyces, Arachnomyces, Anixiopsis and Spiroidum with regard to the effects of methionine, cysteine, S-methyl-cysteine and sodium sulfate on cephalosporin production.The production of cephalosporins by some strains of Cephalosporium and Emericellopsis was markedly stimulated by the addition of methinine to the medium (stimulation group). This stimulaotry effect, however, was not found in other strains of Cephalosporium and Emericellopsis nor in all strains of Paecilomyces, Arachnomyces, Anixiopsis and Spiroidium. Methionine inhibited the production of cephalosporins by some strains of Cephalosporium, Emericellopsis, Paecilomyces, Arachnomyces and Spiroidium. Of the strains of Cephalosporium, all strains of C. chrysogenum and no strains of C. acremonium except Brotzu's strain belonged to the stimulation group.On the other hand, cephalosporin production by all strains of Paecilomyces, Arachnomyces, Anixiopsis, and Spiroidium was markedly stimulated by addition of cysteine to the medium but not by addition of methionine. Cysteine also stimulated cephalosporin production by some strains of Cephalosporium, and inhibited the production by some strains of Emericellopsis.Furthermore, the S-methylcysteine effect was correlated to the methionine effect but not to the cysteine effect. Sodium sulfate slightly stumulated cephalosporin production by some stains and inhibited the production by other strains.From the results on the effects of methionine, cysteine, S-methylcysteine and sodium sulfate on cephalosporin production, the biochemical mechanism of the sulfur metabolism for cephalosporin biosynthesis in C. acremonium CMI 49137 (ATCC 11550) was estimated to be quite similar to that in C. chrysogenum and to be clearly distinguished from that in 9 strains of C. acremonium. Based on these results, the taxonomical position of Brotzu's strain was discussed.

• 社団法人日本生物工学会の論文
• 1977-01-25

著者

• KITANO KAZUAKI

  Microbiology Research Laboratories

• Kitano Kazuaki

  Microbiological Research Laboratories Central Research Division Takeda Chemical Industries Ltd.

• KINTAKA KAZUHIKO

  Microbiological Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.

• NAKAO YOSHIO

  Microbiological Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.

• Nakao Yoshio

  Microbiological Research Laboratories Central Research Division Takeda Chemical Industries Ltd.

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• Comparative Study of Methionine Effect on Cephalosporin Production by Various Fungi : Studies on the Production of β-Lactam Antibiotics (VIII)
• Kinetic Study on the Production of Alkaline Protease by Fusarium sp. No. 5-128
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