Use of an Hfr Strain of E. coli for Prescreening of Antitumor antibiotics

スポンサーリンク

概要

• 論文の詳細を見る

• An Hfr strain if Escherichia coli integratively suppressed by plasmid F showed high susceptibility to agents interacting with DNA at high temperature. Antitumor antibiotics, such as bleomycin, mitomycin C, netropsin, and streptonigrin, which interact with DNA, and intercalating dyes, such as acriflavine, 9-aminoacridine and ethidium bromide, were active in assays of preferential activity against the growth of the Hfr strain at 42°C. In the culture fluid of an actinomycete, dnacins, a new type of antibiotic interacting with DNA, were detected by this assay.

• 社団法人 日本農芸化学会の論文

著者

• Yoneda Masahiko

  Microbiological Research Laboratories Central Research Division Takeda Chemical Industries Ltd.

• HASEGAWA Toru

  Microbiological Research Laboratories, Central Research Division, Takeda Chemical Industries

• YONEDA Masahiko

  Microbiological Research Laboratories, Central Research Division, Takeda Chemical Industries

• TANIDA Seiichi

  Microbiological Research Laboratories, Central Research Division, Takeda Chemical Industries

関連論文

• Sulfazecin, a Novel β-Lactam Antibiotic of Bacterial Origin : Discovery, Fermentation and Biological Characterization
• Use of an Hfr Strain of E. coli for Prescreening of Antitumor antibiotics

スポンサーリンク