^<13>C法における胃排出能評価の指標について-T_<max>を中心に(第2部論文集2-8)(<特集>^<13>C呼気試験法胃排出能検査の現状と未来 : 標準化に向けて)

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There have been many studies about the diagnosis of gastric emptying using ^<13>C-octanoic acid breath test (^<13>C-OABT) since 1993 when Ghoos et al. (1993) first reported, and various index of ^<13>C-OABT was investigated for the correct diagnosis. Especially, the half empting time (T_<1/2>) calculated from fitting curve and the maximum peak time (T_<max>) obtained by the actual ^<13>C-excreation curve are used most frequently. However, some discrepancy between T_<1/2> and T_<max> in the same subject is observed. In this report, we compared T_<1/2> with T_<max> and discussed usefulness and problems of ^<13>C-OABT. Subjects were 20 healthy volunteers and 55 patients with suspect of delayed gastric empting ; 50 with Diabetes Mellitus and 5 with functional dyspepsia. The subjects consumed a standard 280 kcal test meal consisting of 100 mg of ^<13>C-octanoic acid. Breath samples were obtained before and every 15 min. after the consuming of test meal for a total of 6h. Correlation between T_<1/2> and T_<max> was examined. As results, a significant correlation between T_<1/2> and T_<max> was observed (r=0.84). However, the diagnosis of T_<1/2> did not agree with that of T_<max> in 29.7% ; 15 of 37 patients diagnosed as delayed gastric emptying by T_<1/2> were judged normal by T_<max>. The ^<13>C-excreation curve of these 15 patients showed delayed recovery in late phase. We speculated this delayed recovery did not result in true delayed gastric emptying but was the consequence of metabolic effect probably due to liver function. If so, the diagnosis using T_<max> is considered more accurate than that using T_<1/2> in ^<13>C-OABT, however requiring further study to confirm this speculation.
日本平滑筋学会の論文
2002-12-27

^<13>C法における胃排出能評価の指標について-T_<max>を中心に(第2部論文集2-8)(<特集>^<13>C呼気試験法胃排出能検査の現状と未来 : 標準化に向けて)

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