THE EFFECTS OF CLASS IA ANTIARRHYTHMIC DRUG ON THE COMMON TYPE OF ATRIAL FLUTTER IN COMBINATION WITH PACING THERAPY

概要

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In 11 patients with common type of atrial flutter (common AF), rapid atrial pacing from the high right atrium was performed before and/or after class Ia antiarrhythmic drug administration, confirming transient entrainment by decreasing the pacing cycle length by 10ms.. In 10 patients before the drug administration, common Af was not interrupted although the pacing cycle length was decreased to 200 ms in 5 patients, accelerated atrial flutter or atrial fibrillation was induced in 4 patient. After the drug administration common AF was common Af was converted into sinus rhythm in 5 out of 6 patients. The class Ia antiarrhythmic drug prolonged the common AF cycle length (255 ± 12 ms vs. 298 ± 37 ms, p<0.005) and widened the entrainment zone (64 ± 7 ms vs. 90 ± 20 ms, p<0.05). The widening of the entrainment zone and the prolongation of the common AF cycle length facilitate the successful conversion of common Af at a longer pacing cycle length, which would not precipitate atrial fibrillation or accelerated atrial flutter. The combination therapy of rapid atrial pacing and the class Ia antiarrhythmic drug is thought to be useful in the therapy of common AF.
社団法人日本循環器学会の論文
1989-03-20