HEART RATE RESPONSES TO AUTONOMIC DRUGS IN SICK SINUS SYNDROME : Correlation with Syncope and Electrophysiologic Data

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概要

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• To assess the influence of autonomic regulation on automaticity in patients with intrinsic sinus node dysfunction, heart rate responses to autonomic drugs were evaluated in 28 patients with sick sinus syndrome and in 8 normal subjects. Heart rates before and after intravenous administration of isoproterenol (Isp), propranolol, atropine, and methoxamine were measured. To compare the results with electrophysiologic data, heart rate and automaticity recovery time (ART) before and after pharmacologic autonomic blockade (AB) were evaluated. Seventeen patients without syncope showed a similar heart rate response after administration of Isp to that of normal subjects, but 11 patients with syncope showed a significantly lower response than patients without syncope. Responses to atropine and methoxamine were lower and response to propranolol was larger in patients as compared to normal subjects. However, no significant difference was observed between patients with and without syncope. Twelve patients showed severely prolonged max ART exceeding 5000 msec after AB. Seven of them showed preserved response to Isp and max ART be-fore AB was significantly shorter than that after AB. The other 5 patients with lower response to Isp showed no significant change in max ART before and after AB. In conclusion, sympathetic regulation in patients with preserved response to Isp might compensate for the impaired intrinsic automaticity in preventing syncope even in patients with severely impaired intrinsic sinus node function.

• 社団法人日本循環器学会の論文
• 1991-01-20

著者

• Fukuzaki H

  Miki City Hospital Department Of Cardiology

• Inoh Tsutomu

  Kobe University School Of Medicine First Department Of Internal Medicine

• Inoue Tomoo

  First Department Of Internal Medicine Kobe University School Of Medicine

• OGAWA HIDEMI

  The First Department of Internal Medicine, Kobe University, School of Medicine

• INOUE TOMOO

  The First Department of Internal Medicine, Kobe University, School of Medicine

• MIWA SHUSHUKE

  The First Department of Internal Medicine, Kobe University, School of Medicine

• FUJIMOTO TOSHINORI

  The First Department of Internal Medicine, Kobe University, School of Medicine

• OHNISHI YOSHIO

  The First Department of Internal Medicine, Kobe University, School of Medicine

• FUKUZAKI HISASHI

  The First Department of Internal Medicine, Kobe University, School of Medicine

• Ohnishi Yoshio

  First Department of Internal Medicine Kobe University School of Medicine

• Inoh Tsutomu

  The First Dept of Int Med Kobe University School of Medicine

• Ogawa Hidemi

  The First Department Of Internal Medicine Kobe University School Of Medicine

• Miwa Shushuke

  The First Department Of Internal Medicine Kobe University School Of Medicine

• Fukuzaki Hisashi

  The First Department Of Internal Medicine Kobe University School Of Medicine

• Ohnishi Yoshio

  The First Department Of Internal Medicine Kobe University School Of Medicine

• Ohnishi Yoshio

  Division Of Cardiovascular And Respiratory Medicine Department Of Internal Medicine Kobe University

• Fukuzaki Hisashi

  Department Of Thoracie Srugery Osaka Medical College

• Fukuzaki Hisashi

  Dept Of Intern Med. Div. I Kobe Univ. School Of Med.

• Ohnishi Yoshio

  First Department Of Internal Medicine. Kobe University School Of Medicine

• Fukuzaki Hisasi

  Dept. of Intern. Med. Kobe Univ. school of Med.

• Fukuzaki Hisashi

  The First Department Of Internal Medicine Kobe University

• Fujimoto Toshinori

  The First Department Of Internal Medicine Kobe University School Of Medicine

• Inoue Tomoo

  From The First Department Of Internal Medicine Kobe University School Of Medicine

• Fukuzaki Hisashi

  Dept. Of Int. Med. Div1 Kobe Univ.

• Inoue Tomoo

  Kobe University School Of Medicine First Department Of Internal Medicine

• Fukuzakl Hisashi

  The First Department Of Internal Medicine Kobe University School Of Medicine

• Fukuzaki Hisashi

  1st Dep. Of Internal Med. Kobe Univ.

• Fukuzaki Hisashi

  Department Of Thoracic Surgery Osaka Medical College

• Fukuzaki Hisashi

  Internal Medicine Division I Kobe University

• Fukuzaki Hisashi

  The 1st.dept.of Inter. Med Kobe Univ. School Of Med.

• Inoue Tomoo

  The First Department Of Internal Medicine

• Inoue Tomoo

  First Department Of Internal Medicine. Kobe University School Of Medicine

• Ohnishi Yoshio

  Division Of Cardiovascular And Respiratory Medicine Department Of Internal Medicine Kobe University

• Fukumoto Hitoshi

  Department Of Thoracie Srugery Osaka Medical College

• Fukuzaki Hisashi

  First Department Of Internal Medicine. Kobe University School Of Medicine

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