RELATION BETWEEN REGIONAL CONTRACTILE DYNAMICS AND MYOCARDIAL LESIONS IN PATIENTS WITH HYPERTROPHIC CARDIOMYOPATHY

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概要

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• To investigate the influence of wall hypertrophy and myocardial lesions on the regional contractile dynamics of the left ventricle (LV) in patients of hypertrophic cardiomyopathy (HCM), we obtained the thicknesses of the ventricular septum (VS) and posterior wall at end-diastole and systole (E.Td, E.Ts) from echocardiograms made before death for 11 patients of HCM and 6 patients of secondary concentric hypertrophic heart disease (SHH), and the percent regional systolic wall thickening normalized by that of 15 normal controls (%NRWT). We then compared the %NRWT with the pathological wall thickness (P. T.), myocyte diameter (MD), and percent areas of fibrosis (%F) and disarray (%D) in specimens of the corresponding portion from each autopsied heart. The %NRWT in the VS of HCM patients was significantly less than that in SHH patients. All of the MD, %F and %D in the LV wall of HCM patients were significantly greater than those in SHH patients. The %NRWT in the LV wall of HCM patients and SHH patients correlated inversely with the E.Td (r=-0.53, p<0.02 and r=-0.70, p<0.02. respectively), but not with the E.Ts or P.T. The %NRWT in the LV wall of HCM patients had an inverse correlation with the %F (r=-0.59, p<0.005). Furthermore, that in the VS had an inverse relationship with the %D (r=-0.63, p<0.05). Thus, it is suggested that not only LV hypertrophy, but also LV myocardial lesions affect the abnormality of the regional LV contractile dynamics in HCM patients. In addition, observation of the regional contractile dynamics by echocardiography may be useful for speculating on myocardial lesions associated with this disease.

• 社団法人日本循環器学会の論文
• 1989-11-20

著者

• Yokota Yoshiyuki

  Division Of Cardiovascular And Respiratory Medicine Kobe University Graduate School Of Medicine

• Yokota Yoshiyuki

  The First Department of Internal Medicine, Kobe University School of Medicine

• Fukuzaki Hisashi

  The First Department Of Internal Medicine Kobe University School Of Medicine

• Yasaka Yoshinori

  Department Of Cardiology Himeji Cardiovascular Center

• Yoshida Y

  Faculity Of Health Science Kobe University School Of Medicine

• FUKUZAKI Hisashi

  三木市民院循環器内科

• Fukuzaki Hisashi

  Department Of Thoracie Srugery Osaka Medical College

• Fukuzaki Hisashi

  Dept Of Intern Med. Div. I Kobe Univ. School Of Med.

• USUKI SEICHIRO

  The First Department of Internal Medicine, Kobe University School of Medicine

• ITOH HIROSHI

  The First Department of Pathology, Kobe University School of Medicine

• Fukumoto Hitoshi

  Department Of Thoracic Surgery Osaka Medical College

• Fukuzaki Hisashi

  The First Department Of Internal Medicine Kobe University

• Yokota Yoshiyuki

  The First Department Of Internal Medicine Kobe University School Of Medicine

• Yokota Yoshiyuki

  The 1st Department Of Internal Medicine Kobe University School Of Medicine

• Yokota Yoshiyuki

  The First Department Of Internal Medicine

• Usuki Seiichiro

  The First Department Of Internal Medicine Kobe University School Of Medicine

• Fukuzakl Hisashi

  The First Department Of Internal Medicine Kobe University School Of Medicine

• Fukuzaki Hisashi

  Department Of Thoracic Surgery Osaka Medical College

• Fukuzaki Hisashi

  Internal Medicine Division I Kobe University

• Usuki Seichiro

  The First Department Of Internal Medicine Kobe University School Of Medicine

• Yokota Yoshiyuki

  First Department Of Internal Medicine Kobe University School Of Medicine

• Itoh Hiroshi

  The First Department Of Pathology Kobe University School Of Medicine

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