A Mechanism of Catecholamine Tolerance in Congestive Heart Failure : Alterations in the hormone sensitive adenylyl cyclase system of the heart : COMPENSATORY MECHANISMS AND THEIR LIMITATIONS IN HEART FAILURE
スポンサーリンク
概要
- 論文の詳細を見る
It is well known that failing hearts show diminished responsiveness (desensitization) to catecholamines. In this study, 2 different animal models were used to investigate the alterations in the hormone sensitive cardiac adenylyl cyclase system in a congestive heart failure. In the first model, cardiomyopathic Syrian hamsters (BIO53.58), we found reduced activity of the catalytic protein of adenylyl cyclase; this reduction was more prominent in an older animals (28-week-old vs 16-week-old). At both ages, the amount of inhibitory GTP-binding protein (G_i) was markedly increased in BIO53.58 compared to control healthy hamsters. Moreover the increased G_i Was shown to be fully functional in the inhibitoty pathway of the adenylyl cyclase system. In the second model, chronically norepinephrine-infused rats, we found a decrease in B-adrenergic receptor density at an early stage of injection (3 days), while the activity of catalytic protein decreased beyond 14 days of injection, and the amount of G_i increased after 7 days of injection. These results suggest that increased plasma catecholamine concentrations in the setting of congestive heart failure might be a major trigger for qualitative and quantitative alterations observed in various components of cardiac adenylyl cyclase system, and that GTP-binding proteins and catalytic protein of adenylyl cyclase are involved in the mechanism of desensitization especially after chronic in vivo stimulation of adrenergic receptors.
- 社団法人日本循環器学会の論文
- 1992-05-20
著者
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Urasawa Kazushi
Department of Cardiology, Hokkaido University Graduate School of Medicine
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Kawaguchi Hideaki
Department of Laboratory Medicine, Hokkaido University Graduate School of Medicine
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YASUDA HISAKAZU
Department of Cardiovascular Medicine, Hokkaido University School of Medicine
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SATO Katsuhiko
Department of Physics, Kyoto University
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Urasawa Kazushi
Department Of Cardiology Hokkaido University Graduate School Of Medicine
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Yasuda Hisakazu
Department Of Cardiology Hokkaido University School Of Medicine Sapporo
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IGARASHI YASUMI
Department of Cardiovascular Medicine, Hokkaido University School of Medicine
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Kawaguchi Hideaki
Department Of Cardiovascular Medicine Hokkaido University School Of Medicine
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Kawaguchi Hideaki
Department Of Cardiovascular Medicine Hokkaido University
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Igarashi Yasumi
Department Of Cardiovascular Medicine Hokkaido University School Of Medicine
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Sato Katsuhiko
Department Of Cardiovascular Medicine Hokkaido University School Of Medicine
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Yasuda Hisakazu
Department Of Cardiology Hokkaido University School Of Medicine
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Yasuda Hisakazu
Department O F Cardiovascular Medicine Hokkaido University School Of Medicine
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