Wire-Induced Myocardial Ischemia : A Novel Approach to Create Myocardial Ischemia in Rats
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概要
- 論文の詳細を見る
Background Animal models are indispensable in order to investigate the mechanism of various diseases and to explore the counter measures for those disease states. Although there are several animal models of ischemic heart diseases, surgical interventions required to create myocardial ischemia sometimes give rise to a problem in the yield of model. This study describes a new technique for inducing myocardial ischemia in rats. Methods and Results A 0.014-inch guidewire was introduced via the carotid artery and selectively advanced into the coronary arteries under fluoroscopy. Transmural myocardial ischemia was confirmed by ST-segment elevation and by the appearance of left ventricular wall motion abnormalities on the echocardiogram. Reversibility of the wire-induced myocardial ischemia was demonstrated by complete resolution of both ST-segment elevation and wall motion abnormalities after removing the wire. Conclusion Wire-induced myocardial ischemia was reproducible and is less invasive than conventional ischemic models in rats. This method is a powerful and useful tool for the investigation of ischemic heart disease in small animals.
- 社団法人日本循環器学会の論文
- 2004-03-20
著者
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Kitabatake Akira
Department of Cardiovascular Medicine, Graduate School of Medicine, Hokkaido University
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Akioka Kaname
大阪市立大学 医学部循環器病態内科学
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Kitabatake Akira
北海道大学 大学院医学研究科循環病態内科学
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Urasawa Kazushi
Department of Cardiology, Hokkaido University Graduate School of Medicine
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Urasawa Kazushi
Cardiovascular Cnter, Tokeidai Memorial Hospital
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Akioka Kaname
Osaka City University Medical School
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Sakai Hidetsugu
Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine
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Oyama Naotsugu
Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine
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Kaneta Satoshi
Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine
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Saito Takahiko
Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine
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Urasawa Kazushi
Department Of Cardiovascular Medicine Hokkaido University Graduate School Of Medicine
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Urasawa Kazushi
Department Of Cardiology Hokkaido University Graduate School Of Medicine
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Kitabatake Akira
Department Of Cardicvascular Medicine Hokkaidou University
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Kaneta Satoshi
Department Of Cardiovascular Medicine Hokkaido University Graduate School Of Medicine
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Oyama Naotsugu
Department Of Cardiovascular Medicine Hokkaido University Graduate School Of Medicine
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Saito Takahiko
Department Of Cardiovascular Medicine Hokkaido University Graduate School Of Medicine
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Sakai Hidetsugu
Department Of Cardiovascular Medicine Hokkaido University Graduate School Of Medicine
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Sakai Hidetsugu
Department Of Biology Nihon University School Of Dentistry
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Urasawa Kazushi
Deaprtment Of Cardiovasular Medicine Hokkaido University Graduate School Of Medicine
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