Interaction of Platelets and Blood Vessels : Vascular injuries induced by platelet activation in vivo : ROLES OF VASCULAR ENDOTHELIUM IN REGULATION OF CARDIOVASCULAR SYSTEM
スポンサーリンク
概要
- 論文の詳細を見る
We have found that vascular injuries are induced by intravascular aggregation of platelets activated by arachidonic acid (AA) or ADP. The characteristic findings are the appearance of vacuoles in endothelial cells and eventual deendothelialization. In deendothelialized regions, formation of platelet thrombi was observed. The platelets in the thrombi were stained with 2T60, a monoclonal antibody that recognizes activated platelets. The change was more remarkable in the AA-injected animals because AA has a stronger platelet activating effect and a detergent effect on the endothelium. The ADP-injection experiments clarified the role of platelets in vascular injury. These findings suggest that activated platelets play a role in the genesis of vascular injuries, and that their role is related to thrombus formation.
- 社団法人日本循環器学会の論文
- 1992-02-20
著者
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Tanoue Kenjiro
Department of Cardiology, Tokyo Women's Medical University
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Fujimoto Tsukasa
Department of Neurosurgey,Tokyo Medical and Dental University
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Tanoue Kenjiro
Department Of Cardiology Heart Institute Tokyo Women's Medical University
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Tanoue K
Tokyo Metropolitan Inst. Medical Sci. Tokyo Jpn
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Tanoue Kenjiro
Department Of Cardiovascular Research Tokyo Metropolitan Institute Of Medical Science
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AKAMATSU Noriko
Department of Cardiovascular Research, Tokyo Metropolitan Institute of Medical Science
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SUZUKI Hidenori
Department of Dermatology, Graduate School of Biomedical Sciences, Hiroshima University
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Yamaguchi A
Tsukuba Research Laboratories Eisai Co. Ltd.
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Yamaguchi Atsumi
Department Of Cardiovascular Research The Tokyo Metropolitan Institute Of Medical Science
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Tanoue K
Department Of Cardiovascular Research Tokyo Metropolitan Institute Of Medical Science
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Suzuki Hidenori
Department Of Cardiovascular Research Tokyo Metropolitan Institute Of Medical Science
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Yamazaki Hiroh
Department Of Cardiovascular Research The Tokyo Metropolitan Institute Of Medical Science
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Yamazaki Hiroh
Department Of Cardiovascular Research Tokyo Metropolitan Institute Of Medical Science
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KATAGIRI YASUHIRO
Department of Cardiovascular Research, The Tokyo Metropolitan Institute of Medical Science
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Fujimoto Tsukasa
Department Of Neurosurgery Faculty Of Medicine Tokyo Medical:dental University
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Akamatsu Noriko
Department Of Cardiovascular Research The Tokyo Metropolitan Institute Of Medical Science
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Katagiri Yasuhiro
Department Of Cardiovascular Research The Tokyo Metropolitan Institute Of Medical Science
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Suzuki Hidenori
Department Of Cardiovascular Research The Tokyo Metropolitan Institute Of Medical Science
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Suzuki Hidenori
Department of Applied Physics, Tokyo University of Science, 1-3 Kagurazaka, Shinjuku-ku, Tokyo 162-8601
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