ANALYSIS OF THE MECHANISM OF ACUTE DECREASE OF BLOOD PRESSURE INDUCED BY CAPTOPRIL (SQ 14,225) IN DOGS BY THE USE OF APROTININ, SAR^1-ILE^8-ANGIOTENSIN II AND INDOMETHACIN
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概要
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Acute effects of captopril (SQ 14 225) on blood pressure were investigated in pentobarbital anesthetized dogs. Intravenous captopril (0.1 -3 mg/kg) caused reduction of blood pressure dose-independently, while dose-dependent attenuation of exogenous angiotensin I-induced pressor response and potentiation of bradykinin-induced reduction of blood pressure were observed with the same doses of this agent. This acute decrease in blood pressure was partially inhibited by a pretreatment with any one of aprotinin, Sar^1-Ile^8-angiotensin II and indomethacin. More significant inhibition of the blood pressure decrease was observed after the combined pretreatment with Sar^1-Ile^8-angiotensin II and indomethacin or that with all the three drugs, though no complete abolition of the blood pressure decrease was achieved. These results suggest that captopril may decrease blood pressure in anesthetized dogs through other mechanism(s) in addition to angiotensin converting enzyme inhibition, including the prostaglandin release probably from the kidney.
- 社団法人日本循環器学会の論文
- 1981-06-20
著者
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Ohara Naoki
Laboratory Of Pharmacology Hatano Research Institute Food And Drug Safety Center
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Ohara Naoki
Laboratory Of Applied Pharmacology Hatano Research Institute Food And Drugs Safety Center
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Hashimoto Koroku
Laboratory of Pharmacology, Hatano Research Institute, Food & Drug Safety Center
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Ono Hiroshi
Laboratory Of Entomology Obihiro Zootechnical University
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Hashimoto Koroku
Laboratory Of Pharmacology Hatano Research Institute Food & Drug Safety Center
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Ono Hiroshi
Laboratory Of Pharmacology Hatano Research Institute Food And Drug Safety Center
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Hashimoto Koroku
Laboratory Of Pharmacology Hatano Research Institute Food And Drug Safety Center
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HASHIMOTO Koroku
Laboratory of Genetics, Hatano Research Institute
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