The effects of organic extract of diesel exhaust particles on ischemia/reperfusion-related arrhythmia and on pulmonary inflammation
スポンサーリンク
概要
- 論文の詳細を見る
Since our previous study demonstrated the exacerbation of acute myocardial ischemia/reperfusion (AMIR)-related arrhythmia by intratracheal instillation (IT) of diesel exhaust particles (DEP), the influence of IT with extracts of DEP in organic solvents on AMIR-related arrhythmia was examined in rats. Oxidative activity in a non-biological assay system and proinflammatory activity in mice of DEP extracts were examined. The dichloromethane-soluble fraction (DMSF) of DEP was further fractionated into n-hexane-soluble (n-HSF) and n-hexane-insoluble (n-HISF) fractions. The oxidative activities of the fractions evaluated by dithiothreitol assay were ranked as follows: n-HISF>DMSF>n-HSF. Twenty-one to 34hr after IT, the AMIR experiment was performed. Exacerbation of AMIR-related arrhythmia and increased reperfusion-related mortality were observed only in rats treated with DMSF. In fact, n-HSF and n-HISF did not affect arrhythmia up to 5mg/kg. Twelve hr after IT, a significant increase in neutrophil count was observed only with DMSF. The levels of granulocyte colony-stimulating factor and interleukin-6 in bronchoalveolar lavage fluid were significantly elevated in the group treated with DMSF, while neither, n-HSF nor n-HISF, affected the level of cytokines up to 5mg/kg. In fact, tumor necrosis factor-α, IL-10 and granulocyte-macrophage colony-stimulating factor were unchanged with any of the fractions. In conclusion, exacerbation of AMIR-related arrhythmia by DMSF suggests the contribution of non-particle components of DEP to arrhythmia while the component contributed to the effects did not become clear. Furthermore, it is confirmed that exacerbation of AMIR-related arrhythmia is accompanied by an increased neutrophil count in the circulatory blood.
- 日本トキシコロジー学会の論文
- 2008-02-15
著者
-
Ohara Naoki
Hatano Res. Inst. Food And Drug Safety Center
-
Ohara Naoki
Laboratory Of Pharmacology Hatano Research Institute Food And Drug Satety Center
-
Yokota Syunji
Laboratory Of Toxicology Hatano Research Institute Food And Drug Safety Center
-
Ohara Naoki
Laboratory Of Applied Pharmacology Hatano Research Institute Food And Drugs Safety Center
-
Kobayashi Takahiro
Environmental Health Sciences Division, National Institute for Environmental Studies
-
Kobayashi Takahiro
Environmental Health Sciences Division National Institute For Environmental Studies
関連論文
- Testosterone-lowering activity of canola and hydrogenated soybean oil in the stroke-prone spontaneously hypertensive rat
- Plasma triglyceride-rich lipoprotein remnants as a risk factor of 'Pokkuri disease'
- "P-76 Effects of Food Restriction on Repeated Doses of Carbon Tetrachloride Toxicity in Rats.
- Dietary intake of rapeseed oil as the sole fat nutrient in wistar rats : Lack of increase in plasma lipids and renal lesions
- Tracheal instillation of diesel exhaust particles component causes blood and pulmonary neutrophilia and enhances myocardial oxidative stress in mice
- Cardioprotective Effects of an Angiotensin-Converting-Enzyme Inhibitor,Imidapril, and Ca2+ Channel Antagonist, Amlodipine, in Spontaneously Hypertensive Rats at Established Stage of Hypertension
- The effects of organic extract of diesel exhaust particles on ischemia/reperfusion-related arrhythmia and on pulmonary inflammation
- PARTICIPATION OF KININS OR PROSTAGLANDINS IN SQ 14, 551-INDUCED IMMEDIATE DECREASE OF BLOOD PRESSURE IN ANESTHETIZED DOGS
- DIFFERENT EFFECTS OF CAPTOPRIL ON BLOOD PRESSURE IN THE ACUTE AND CHRONIC TWO-KIDNEY GOLDBLATT HYPERTENSIVE DOGS
- EFFECT OF AN ANTIANGINAL DRUG, PERHEXILINE, ON MYOCARDIAL OXYGEN CONSUMPTION IN ANESTHETIZED OPEN-CHEST DOGS COMPARED WITH VERAPAMIL AND GLYCERYL TRINITRATE
- POTENTIATION OF BRADYKININ-INDUCED DECREASE OF BLOOD PRESSURE IN DOGS BY SQ 14, 551, THE DISULFIDE METABOLITE OF CAPTOPRIL
- ANALYSIS OF THE MECHANISM OF ACUTE DECREASE OF BLOOD PRESSURE INDUCED BY CAPTOPRIL (SQ 14,225) IN DOGS BY THE USE OF APROTININ, SAR^1-ILE^8-ANGIOTENSIN II AND INDOMETHACIN
- Effects of Perhexiline on Hemodynamics in Anesthetized Open-Chest Dogs