Dietary intake of rapeseed oil as the sole fat nutrient in wistar rats : Lack of increase in plasma lipids and renal lesions
スポンサーリンク
概要
- 論文の詳細を見る
Dietary rapeseed (canola) oil (CO) given as the only fat nutrient shortens life in strokeprone spontaneously hypertensive rats (SHRSP), compared with SHRSP given soybean oil (SO) instead of CO. CO ingestion increases plasma lipids and causes renal lesions in SHRSP and in spontaneously hypertensive rats (SHR), and increases plasma lipids also in Wistar Kyoto (WKY) rats, a normotensive counterpart of SHR. This study examined whether or not such unfavorable effects of CO are restricted to these closely related strains. For this purpose Wistar rats, the strain from which these strains were derived, were fed a diet containing 10% CO or SO as the sole fat nutrient for 10 weeks, and changes in clinical signs, urinalysis, blood biochemistry and pathology were compared. CO ingestion did not induce any abnormalities in Wistar rats, except significant increases in plasma concentrations of aldosterone and Na^+, compared with the SO group. Thus, the unfavorable effects of CO ingestion appear to be restricted to SHRSP and its closely related strains. The role of increased aldosterone and Na^+ in the unfavorable events caused by CO in SHRSP, SHR and WKY rats, and any factors which could induce such increases in aldosterone and Na^+, remain to be elucidated.
- 2008-12-01
著者
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Ohara Naoki
Hatano Res. Inst. Food And Drug Safety Center
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Ohara Naoki
Laboratory Of Pharmacology Hatano Research Institute Food And Drug Satety Center
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Nagata Tomoko
Division Of Toxicology Hatano Research Institute Food And Drug Safety Center
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Okuyama Harumi
Laboratory Of Preventive Nutraceutical Sciences Kinjo Gakuin University College Of Pharmacy:open Res
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Tachibana Shigehiro
Laboratory Of Pharmacology Hatano Research Institute Food And Drug Satety Center
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Naito Yukiko
Laboratory of Pharmacology, Hatano Research Institute, Food and Drug Satety Center
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Ohara Naoki
Division of Toxicology, Hatano Research Institute, Food and Drug Safety Center
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Naito Yukiko
Division of Toxicology, Hatano Research Institute, Food and Drug Safety Center
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Tachibana Shigehiro
Division of Toxicology, Hatano Research Institute, Food and Drug Safety Center
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Okimoto Mari
Division of Toxicology, Hatano Research Institute, Food and Drug Safety Center
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Naito Yukiko
Laboratory Of Pharmacology Hatano Research Institute Food And Drug Satety Center
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Okimoto Mari
Division Of Toxicology Hatano Research Institute Food And Drug Safety Center
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Nagata Tomoko
Division Of Dermatology Organ-oriented Medicine School Of Medicine Faculty Of Medicine University Of
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