Mechanisms of slow contracture induced by potassium and caffeine in skeletal muscle of the dog.
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概要
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Effects of diltiazem (3 μg-0.3 mg), verapamil (3 μg-0.3 mg), tetracaine (30 μg-3 mg), MnCl<SUB>2</SUB> (0.1 mg-10 mg) and CaCl<SUB>2</SUB> (0.1 mg-10 mg) on the skeletal muscle contracture induced by KCI and caffeine infusions were studied in the isolated, blood-perfused canine diaphragm preparation. All drugs were injected intra-arterially. Continuous intra-arterial infusion of KCI (50-100 mg/min) produced a biphasic contracture, which was characterized by a fast phasic contracture and a following tonic contracture. All drugs tested in this study except for CaCl<SUB>2</SUB> produced a dose-dependent relaxation in the state of tonic contracture induced by KCI infusion. Dose-response curves for the relaxation of muscle to these drugs were all in parallel . Diltiazem and verapamil were equipotent and were about 10 and 30 times more potent than tetracaine and MnCl<SUB>2</SUB> on a weight basis. Conversely, CaCl<SUB>2</SUB> produced a contractile response in a dose-dependent manner. On the other hand, diltiazem, verapamil and CaCl<SUB>2</SUB> had almost no effect on contracture induced by continuous intra-arterial infusion of caffeine (20 mg/min). MnCl<SUB>2</SUB> produced a slight relaxation in the caffeine-contracture with much higher doses than those against potassium-contracture. However, tetracaine produced a dose-dependent relaxation of caffeine-contracture. Thus, the results suggest that the entry of external calcium plays an essential role in the potassium-induced tonic contracture and that the potassium- and caffeine-contractures were maintained by different mechanisms.
- 公益社団法人 日本薬理学会の論文
著者
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Ono Hiroshi
Laboratory Of Entomology Obihiro Zootechnical University
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Aoyama Takuo
Research Laboratories Torii And Co. Ltd.
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SATO Takuo
Research Laboratories, Torii & Co., Ltd.
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SATO Takuo
Research Laboratories, Torn & Co., Ltd.
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AOYAMA Takuo
Research Laboratories, Torn & Co., Ltd.
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- Mechanisms of slow contracture induced by potassium and caffeine in skeletal muscle of the dog.