Inhibitory effects of a novel synthetic protease inhibitor, FUT-175, on the paw edema in rats and zymosan-induced complement activation in vitro.
スポンサーリンク
概要
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FUT-175 inhibited the zymosan-induced rat paw edema in a dosedependent manner, while indomethacin exhibited no significant activities in this model. FUT-175 also inhibited the decrease in hemolytic complement (CH50) induced by zymosan in vitro, and indomethacin was inactive. These results suggest that FUT-175 has potent in vitro and in vivo inhibitory activity against the activation of the complement system induced by zymosan.
- 公益社団法人 日本薬理学会の論文
著者
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Oda Minoru
Research Laboratories Torii Pharmaceutical Co. Ltd.
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IWAKI Masahiro
Research Laboratories, Torii & Co. Ltd.
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INO Yoshitaka
Research Laboratories, Torii & Co., Ltd.
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MOTOYOSHI Akemi
Research Laboratories, Torii & Co., Ltd.
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SATO Takuo
Research Laboratories, Torii & Co., Ltd.
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MOTOYOSHI Akemi
Research Laboratories, Torii & Co., Ltd.
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IWAKI Masahiro
Research Laboratories, Torii & Co., Ltd.
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KOSHIYAMA Yoshiko
Research Laboratories, Torii & Co., Ltd.
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