Plasma Endothelin-1 Elevation Associated With Alcohol-Induced Variant Angina

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概要

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• Vasospastic angina as a result of alcohol ingestion has been reported, but the mechanism of alcohol-induced coronary artery spasm is presently unknown. This report presents 2 cases of alcohol-induced variant angina(VA)with elevated levels of plasma endothelin-1 after alcohol ingestion. In case 1, the plasma endothelin-1 concentration was 3.15 pg/ml before frinking(normal <2.30 pg/ml)and increased to 4.09 pg/ml when measured 5 h after alcohol ingestion. After 2 months of abstinence, the plasma endothelin-1 concentration was 2.88 pg/ml and 6 months after abstinence, it decreased to 2.03 pg/ml(normal range). In case 2, the plasma endothelin-1 concentration was 2.44 pg/ml before drinking and increased to 4.36 pg/ml when measured 5 h after alcohol ingestion. After 2 months of abstinence, the plasma endothelin-1 consentration was 3.04 pg/ml and 6 months after abstinence, it decreased to 2.09 pg/ml(normal range). These 2 cases suggest that a relationship may exist between alcohol-induced VA and elevation in the plasma endothelin-1 concentration after alcohol ingestion.

• 社団法人日本循環器学会の論文
• 1999-06-20

著者

• Mizuno Sumio

  金沢大学 循環器内科

• Takahashi Yoshifumi

  Department Of Internal Medicine Fukui Cardiovascular Center

• Takeda Yoshiyu

  北陸中央病院(共済) 内科

• Takeda Yoshiyu

  Division Of Endocrinology And Hypertension Kanazawa University Graduate School Of Medicine

• Mizuno Sumio

  Fukui Cardiovascular Center

• Ohsato Kazuo

  Fukui Cardiovascular Center

• Murakami Tatsuaki

  Fukui Cardiovascular Center

• Moriuchi Ikuo

  Fukui Cardiovascular Center

• Kaku Bunji

  Division Of Cardiology Ishikawa Prefectural Hospital

• Kaku Bunji

  福井県循環器病院

• TAKAHASHI Yoshifumi

  Fukui Cardiovascular Center

• Ohosato Kazuo

  Fukui Cardiovascular Center

• Kaku Bunji

  Fukui Cardiovascular Center

• Arai Yoshiyuki

  Fukui Cardiovascular Center

• Nio Yutaka

  Fukui Cardiovascular Center

• Ohnaka Masateru

  Fukui Cardiovascular Center

• Ohsato Kazuo

  Division Of Cardiology Fukui Cardiovascular Center

• Oe Kotaro

  Molecular Genetics Of Cardiovascular Disorders Division Of Cardiovascular Medicine Graduate School O

• Ohe Koutarou

  Fukui Cardiovascular Center

• Mabuchi Tomohito

  Fukui Cardiovascular Center

• Ohnaka Masateru

  Department Of Cardiovascular Medicine Fukui Cardiovascular Center

• Arai Yoshiyuki

  Deparlment Of Cardioloty Fukui Cardiovascular Center

• Murakami Tatsuaki

  Department Of Internal Medicine Fukui Cardiovascular Center

• Mabuchi Tomohito

  Molecular Genetics Of Cardiovascular Disorders Division Of Cardiovascular Medicine Graduate School O

• Takahashi Yoshifumi

  Second Department Of Internal Medicine School Of Medicine Kanazawa University

• Tuda Yoshinori

  Department Of Pharmacology Kanazawa University

• Takeda Y

  Kanazawa Univ.

• Murakami Tatusaki

  福井循環器病院

• Murakami Tatsuaki

  福井循環器病院

• Murakami T

  福井循環器病院 循環器科

• Takeda Yoshiyu

  Fukui Cardiovascular Center

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