The Correlation Between Coronary Stenosis Index and Flow-Mediated Dilation of the Brachial Artery

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We examined the relationship between flow-mediated dilation(FMD)of the brachial artery and the extent and severity of coronary artery disease(CAD).Using high-resolution ultrasonography, we measured FMD and nitroglycerin-induced brachial artery dilation.We studied 121 patients(77 men, 44 women;mean age 64±11 years, range 25-79 years)who underwent coronary arteriography.The extent and severity of CAD were assessed by the coronary stenosis index(CSI).The adjusted FMD correlated inversely with CSI(r_s=-0.63, p<0.0001).Multivariate analysis demonstrated that the adjusted FMD was an independent predictor of CSI.The adjusted FMD was 10.2±4.8% in patients without CAD(n=32), 7.7±6.0% in patients with single-vessel disease(n=31), 5.2±5.5% in patients with double-vessel disease(n=29), and 2.0±3.9% in patients with triple-vessel disease(n=29).The adjusted FMD was significantly lower in the double-(p<0.01)and triple-vessel(p<0.0001)disease groups than in patients without CAD.The adjusted FMD was significantly lower in the triple-vessel disease group than in the single-vessel disease group(p<0.001).Based on our results, as coronary atherosclerosis becomes more severe, the adjusted brachial artery FMD becomes more severely impaired.
社団法人日本循環器学会の論文
1998-05-20