[SHORT REPORTS]Suppression of Muscarinic Potassium Channel Activation by Intracellular ATP Depletion
スポンサーリンク
概要
- 論文の詳細を見る
The effects of cytoplasmic ATP depletion on the acetylcholine (ACh) activation of the muscarinic K^+ current (i_k,_A_C_h) were examined in guinea-pig atrial cells using the whole-cell patch clamp technique. Internal dialysis with a non-hydrolyzable ATP analogue, AMP-PNP, resulted in a progressive decrease in the amplitude of i_k,_A_C_h. A similar decrease in i_k,_A_C_h was induced by exposing cells to a metabolic inhibitor,2-4-dinitrophenol. These recults indicate that cytoplasmic ATP is required for ACh to activate i_k,_A_C_h. This suggests that there may be a loss of sensitivity to ACh during myocardial ischemia.
- 名古屋大学の論文
著者
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Toyama J
Aichi Prefecture Hospital
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Toyama Junji
名古屋大学 大学院医学系研究科循環器内科
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Toyama Junji
Division Of Cardiology Aichi Prefecture Cardiovascular And Respiratory Center
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Toyama Junji
1st Dept. Of Intern. Med. Nagoya Univ.
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Toyama Junji
Department Of Circulation And Respiration The Research Institute Of Environmental Medicine Nagoya Un
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Toyama Junji
Aichi Prefecture Hospital
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