1516 空気霧化法による微小高分子ゲル粒子の作製

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In this study a model blood was produced in order to use it in the experiment in vitro to simulate human circulation. Real blood consists of red blood corpuscle and blood plasma. Therefore we produced alginic acid gel particles as a model blood cell, and made a dispersion agent consisting of the model blood cells and a solution of calcium chloride as a model blood. A solution of alginic acid sodium was atomized by pressurized air in a nozzle, and was poured on the surface of calcium chloride solution to lead to a chemical reaction to form the alginic acid gel particles. However our model blood cells had the average diameter larger than that of the real red blood corpuscles. In this study we tried to produce the particles having diameters smaller than that of the real red blood corpuscles (about 8.5μm). But we found many irregular shaped particles was produced. So we tried to produce spherical gel particles by changing "alginic acid sodium-concentration" and "chemical reaction system", and compared the average diameter and the in these new condition and in the previous condition diameter distribution of the produced particles.
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