Na-Cu-Chlorophyllin の線維素溶解現象阻止作用について

概要

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Na-Cu-Chlorophyllin (Cu-C) has been reported to be a complement inhibitor by Sindo and coworkers. Nishioka has found that the reactivity of C′5 was blocked by Cu-C, and Nelson has revealed that the interaction of C′1 and antigen-antibody complex was also blocked by Cu-C. Pillemer and coworkers have demonstrated that the inactivation of human C′2 and C′4 by plasmin is an indirect reaction mediated by a factor closely resembling C′1. Kondo and coworkers have found that the PCA reaction is inhibited by plasmin inhibitors, and that enhancement of vascular permeability by intradermal injection of C′1 esterase is also suppressed by plasmin inhibitors. Thus, it has been suggested that some interrelationship between the plasmin and the antigen-antibody-complement system, especially C′1, may exist. The results described herein were obtained from the experiments undertaken on the assumption that Cu-C, the complement inhibitor, may inhibit fibrinolytic activities of the plasmin. The inhibiting ability to the plasmin was examined by means of the standard fibrin plates. It was found that a small amount of Cu-C (5-20γ/ml) inhibit partially fibrinolytic activities of the plasmin.
日本アレルギー学会の論文
1967-09-30