12. 皮膚とプラズマキニン(第2回プラズマキニン研究会)

概要

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The kinins were derived from protein precursor by treatment with kinin-forming enzymes. The enzymes should be proteases. The experiments were done to find out the kinin-formation by the protease extracted from frozen human shin by treatment with KCL solution and acetone. The derived protease might be SH dependent enzyme because of activaiton with cysteine and inhibition with p-chloromercuri benzoate. Heated dog globulin was incubated with the protease in the 37℃ water-bath for thivrty menutes and extracted from 95% of boiling alcohol for five minutes and filtrated and dried. The power was disolved in the distilled water and measured by use of rat uterus in the atropirized Tyrode solution and compared with the extracted kinin prepared from Rocha e Silva. The results showed the remarkable kinin, formation. The amount of kinin in human skin slices was measured. No kinin, however, was detected in human skin of e; even individuals.
日本アレルギー学会の論文
1968-04-30