2.ループス腎炎における血清補体(第3回補体シンポジウム II 各種疾患における補体及び補体成分の変動)

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We report here on the fluctuations of serum complement levels of four patients suffering from the systemic lupus erythematosus (SLE) in relation to their clinical courses. Estimations of C' and I.A. were done according to the original methods of Kabat-Mayer's and Nelson-Nishioka's, respectively. In the patients of SLE, serum complement levels correlated well with their clinical signs and symptoms, esp. fever, exanthema on the cheek, Proteinuria, erythrocytes in the urinary sediment, etc., and the clinical aggravation accompanied lowering of the serum complement. But the degree of renal lesions did not seem directly related to the complement levels. In one patient, whose course we could follow up fairly well clinically, showed low level of the complement in advance to the clinical exacerbation, such as pyrexia. The lowering of the serum complement is observed in only a few renal diseases, and besides SLE, they are, as we report elsewhere, the initial stage of the acute glomerulonephritis and some of the nephrotic syndrome. In the latter there may possibly be included the nephrotic type of SLE. Some authers reported normal or high serum complement in the rheumatic fever or rheumatoid arthritis and hereafter we are going to make further investigation on the serum complement of the collagen diseases in comparison with that of SLE. All of our cases were treated with steroids somewhere in their clinical courses, which seemed to lower the complement level in no way, contrary to some other authers who reported the lowering effect of steroid on the serum complement. Further, we did not observe the decrease of serum complement in guinea pigs after the intramuscular injection of the steroid. As to the anti-complementary effects of the serum from the patients of SLE, we did not consider them at all here in this report. In summary, we estimated the serum complement in four patients of SLE in relation to their clinical courses, with the following results. 1) Decrease of serum complement was closely related with the clinical aggravation of SLF, but it did not directly correlate with the degree of renal lesions. 2) No lowering effects of the steroid on serum complement were observed.
日本アレルギー学会の論文
1966-11-30

2.ループス腎炎における血清補体(第3回補体シンポジウム II 各種疾患における補体及び補体成分の変動)

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