7. 〓痒性皮膚疾患と起炎性物質皮内注射時の皮膚末梢神経所見 : 特にブラディキニン皮内注所見を中心に(第2回プラズマキニン研究会)

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Studies on the morphological changes of the peripheral nerves in pruritic dermatoses were reproted by us for the past several years. It was clarified that the pathologic changes to be provided for a mechanism regarding to pruritic sensation were found in the neuroplasmatic parts of centripetal nerves, whereas there were vacuolated, opaque and/or edematous changes in the nruroplasmic cords of centrifugal nerves. These latter changes seem to suggest a mechanism regarding to edema, wheal and/or inflammatous changes in the terminal biochemical and physical reacting parts. These findings of the centripetal nerve-systems suggest that normal-shaped and almost naked sensory neurofibrils were influenced directly by chemical stimulants in the surrounding tissue fluid and by physical, osmotic pressure changes. On the other hand, those findings of the centrifugal nerve-systems seem to indicate that centrifugal impulses go to ill-direction with some influences upon non-objected tissues or cells. The present studies are as follow; 2.5γ/0.025 ml of Bradykinin was intracutaneously injected into normal skins of a patient with chronic urticaria and one with urticaria pigmentosa. 30 minutes later, the skins were biopsied and subjected to histological examination for siver impregnation following Bielschowski-Suzuki's method. Each of 0.5γ/0.025 ml of histamine HCl, histamine H_3PO_4, 2.5γ0.025 ml of serotonine-creatinine H_2SO_4, 12.5γ/0.025 ml of acetylcholine was intracutaneously injected into normal skins of a patient with chronic urticaria and one with pruritus cutaneus. At the same time, the skins with spontaneously developed wheale lasting for 12 hrs were also biopsid and examined in the same method. Simillar results as already reported were obtained in this study. Various kinds of degeneration were seen in neuroplasma of sensory nerves or mixed nerves and vegetative endformations, particularly in the nerves of the vicinity where degranulated mast-cells in erythematously reacted area were present.
日本アレルギー学会の論文
1968-04-30

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