9.エレドイシン様物質, フィサラミンの皮内注射所見, 補遺 : 反応と皮膚末梢神経像(第4回プラスマキニン研究会)
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Nine phlogogenic gubstances such as Eledoisin-like substance, Physalaemin and Bradykinin were in-jected intradermally and the inhibitory effect of Homoclomin-given orally on the intracutaneous reaction caused by them was observed in 30 subjects. The intradermal reaction caused by 8 of them including Eledoisin-like substance was suppressed was by internal use of Homoclomin-tablet. On the other hand, swelled eruption caused by intracutaneous injection of Physalaemin was not inhibited by oral use of Homo-clomin-in all of the 4 subjects examined. In this case swelled eruption has a strong resemblance to spon-taneous one, though accompanied no subjective symptoms such as itchihg sensation. The state of degra-nulation in mast cells and changes in blood vessels and peripheral nervous elements were compared hitopathologically immediately after an injection of these substances in 0 subjects, in 12 of whom intracu-taneous reaction had been observed. In the four subjects given intradermal injection of Physalaemin the intensity of degranulation was not parallel with changes in peripheral nervous elements. Regarding the intensity of degranulation Physalaemin held the sixth rank in 9 substances. On the contrary, it was ranked first with regards changes in blood vessels and peripheral nervous elements. At least in those 4 cases, therefore, it was hard to consider that degranulation of mast cells played a so important role in genesis of swelled eruption by Physalaemin. The networks of peripheral vegetative and viscero-sensory nervous elements with reactive capillaries in the papillae of the skin was regarded as rather important.
- 日本アレルギー学会の論文
- 1970-08-30
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