1. ブラジキニンエレドイシン様物質, フィサラシンの皮内注射時の皮膚病理組織学的所見.(とくに, 末梢神経所見について)(第1報)

概要

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The present studies were made follows; 0.5 γ/0.025 ml of Bradykinin, 0.05 /0.025 ml of Eledoisin-like Substance (Lys-Phe-Ileu-Gly-Leu-Met-NH_2 ・ 2Hcl) and 0.025 γ/0.025 ml of Physalaemin were intracutaneously injected into normal-looking skins of patients with chronic urticaria (Bradykinin=2 cases, Eledoisin-like Substance=3 cases and Physalaemin=4 cases). 20 minutes and/or 30 minutes later, the skins were biopsied and subjected to histological examination for silver impregnation following Bielschowski-Suzuki's method and other mast-cell-stains. At the same time, the skins with spontaneously developed wheales lasting for 5 hrs. (2 cases) were also biopsied and examined in the same methods. Similar results as already reported^<l)2)> were obtained in this study. Various kinds of degeneration were seen in neuroplasma of sensory nerves or mixed nerves and vegetative endformations, particularly in nerves in the vicinity of dilatated capillaries where degranulated mast-cells were found in erythematously reacted area with various degrees of wheals were present. Eledoisin-like Substance atacked at the sensory neurofibrils. This substance was suggested painproducing Substance, especialy. Physalaemin atacked at the vegtateive endformations and neuroplasma and capillary-wall, especially. These substances may have direct influences at the peripheral nervous systems and/or capillary-walla.
日本アレルギー学会の論文
1969-06-30