Compound 48/80皮内注射時の皮膚末梢神経所見

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0.0125 mg/0.05 ml or 0.00625 mg/0.025 ml of Compound 48/80 was intracutaneously injected into normal skins of 3 patients with chronic urticaria. 30 minutes later, the skins were biopsied and subjected to histological examination with silver impregnation following Bielschowski-Suzuki's method. The following findings were obtained: (1) In the papilla of the dermis and middermis, mixed nerves and endformations of vegetative nerves showed hypoargyrophilic and vacuolated degeneration with opaque swellling. These findings were observed also in other parts of the dermis, especially, so-called "neuro-swelling-parts" of subpapillary layer clearly. (2) The sensory nerves showed poorly argyrophilic, vacuolated and opaque degenerations and swelling of the neuroplasmas. (3) Degranulation of mast cells was more remarkably than in the case produced by intracutaneous injection of bradykinin. The granules were seen mostly in the vicinity of the nerves and blood vessels. (4) In the vegetative endformations of the neighbourhood of Schwann's nuclei on the blood vessel-walls, argyrophilic granules were increased and grouped. (5) These findings of the vegetative endformations suggest that centrifugal impulses go to ill-direction and have influences upon non-objected tissues or cells. (6) That findings of sensory nerves were observed as common findings in pruritic dermatoses and suggested that chemical stimulants from the surrounding tissue fluid or physical, osmotic pressure changes may greaty influence on the "naked" neurofibrils in these areas.
日本アレルギー学会の論文
1967-07-30

Compound 48/80皮内注射時の皮膚末梢神経所見

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