空洞形成阻止に関する実験的研究 : ブドウ球菌空洞形成阻止

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Ogawa et. al have previously reported that the cavitation by infection of staphylococci was promoted by antigen-antibody reaction and that intravenous inoculation with heat-killed staphylococci suspended in saline induced protective effect against the cavitation. Accoring to these findings, it was attented to prevent the formation of cavities and/or necrosis in the lungs of guinea pigs and rabbits. To produce the cavities, either sensitized or nonsensitized animals with heat-killed staphylococci were injected into the lungs with same killed bacilli. To prevent the formation of cavities, procedures were used as follows. Animals (1) were subcutaneously injected daily with various doses of cortisone acetate, "Strong Neo-Minophagen C" and "Glycyron" and (2) were intravenously injected three times a week with heat-killed staphylococci suspenedd in saline. Two or four weeks after pulminary injection, animals were sacrificed for post-mortem examinations. Serum agglutination tests were performed on all animals once a week. The titers of animals treated with anti-allergics were lower than that of the non-treated animals. On the contrary, when the animals were injected intravenously with the bacillary cells, their agglutination titers were higher than that of the non-treated animals. Productive and proliferative changes were pronounced in the lungs of treated animals, while intensively exudative as well as necrotic and cavernous changes were found in those of the non-treated animals. From these findings, the authors suggested that the repeated injections of anti-allergics or antigen appear to have altered the usual process of development of necrotic and cavernous lesion.
日本アレルギー学会の論文
1966-01-30

空洞形成阻止に関する実験的研究 : ブドウ球菌空洞形成阻止

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