STUDIES ON LETHAL FACTORS IN EXPERIMENTAL MURINE TUBERCULOSIS

元データ 一般社団法人 日本結核病学会

概要

Survival test has hitherto been used as the method for measuring the virulence of tubercle bacilli or the effect of chemotherapeutics against tuberculosis. In these experiments, the median suvival time was most useful, and it was already shown that there existed a certain correlation between the size of infecting dose and the median survival times. This was the case with infecting the mice with a moderate dose. However, when mice were infected with either a large dose or a small dose of tubercle bacilli, no such correlation was found. Also the distri bution of the death times in this case was different from that of the infection with a moderate dose. We have reported also that the survival curve was composed of three phases. It will be shown in the present paper that the cause of death of mice might not be similar in each death phase. The results were the following.

著者

山県 英彦 国立療養所刀根山病院
寺井 武雄 国立療養所刀根山病院
永管 徳子 国立療養所刀根山病院

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