実験的結核病巣における蛋白分解酵素の研究

概要

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In order to clarify the correlation between the tuberculous cavity formation and the proteolytic enzyme activity in the pulmonary tissue, we have studied the autolytic prote elysis in the experimental tuberculous lesion which was formed by the injection of the heat killed H37Rv into rabbit lungs. Conclusions are summarized as follows: 1. The proteolytic activity in tuberculous lesion was several times higher than that in normal lung tissue. 2. The lung weight and the total proteolytic activity of the lung were increased according to the development of pathological changes after the intrapulmonary injection of bacilli, and decreased during the recovery processes. 3. The above phenomena were amplified and accelerated by the presensitization treatment, and were depressed by the sequential i. v. injection of PPD. 4. Although there are many kinds of proteases in the tuberculous lung, the lysosomal thiol protease in the alveolar macrophages should be playing the important roles in this tissue. 5. A new thiol protease, which was little activity in normal lung tissue, was found markedly in the tuberculous lesion and in alveolar macrophages as well.
一般社団法人日本結核病学会の論文