Comparisons of Pulmonary Carcinogenesis in Rats Following Inhalation Exposure to Plutonium Dioxide or X-ray Irradiation
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概要
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Radiation-induced pulmonary carcinogenesis was compared in female Wistar rats following either inhalation exposure to alpha-emitting ^<239>PuO_2 aerosols, whole-body or thoracic X-ray irradiation. Dose-dependent survival reduction was correlated with increased malignant lung tumors at doses over 0.45 Gy, reaching the maximum incidence of 90% at 6.6-8.5 Gy in ^<239>Pu-exposed rats. While the differential dose responses for each histopathological type of tumors were noted, almost 70-80% were carcinomas among all of the primary tumors from ^<239>Pu-exposed rats. As the dose response curves for lung carcinomas were compared, the slope of the fit linear equation and the calculated relative effectiveness for 50% incidence of lung carcinomas were approximately 11-times as high in ^<239>Pu-exposure as those of thoracic X-irradiation. The numbers of tumor lesions distributed in the lung per tumor-bearing animal were about 2-fold more in ^<239>Pu-exposed rats, while the proportions of their histopathological types were similar between ^<239>Pu-exposure and X-irradiation. These results indicate that the magnitudes of the relative effectiveness or risk for pulmonary carcinogenesis are greater in ^<239>Pu-exposure than X-irradiation, and that radiation-induced lung tumors appear to originate mostly from the same target epithelial cells.
- 日本放射線影響学会の論文
著者
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Oghiso Yoichi
Internal Radiation Effects Research Group National Institute Of Radiological Sciences
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Oghiso Yoichi
Internal Radiation Effects Research Group Research Center For Radiation Safety National Institute Of
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Yamada Yutaka
Internal Radiation Effects Research Group Research Center For Radiation Safety National Institute Of
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Yamada Yutaka
Internal Radiation Effects Research Group Research Center For Radiation Safety National Institute Of
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