Combined Effects of Radiosensitizers and Radioprotectors on Cultured Mammalian Cells to Co-60 γ-Rays

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The combined, effects of misonidazole and cysteamine on the colony-forming ability of hypoxic cultured mouse leukemic L5178Y cells showed much greater protection at low cyste-amine concentrations than could be expected from the protection and sensitization by the administration of each of these drugs. Similar effects, but less protection than the case of misonidazole plus cysteamine were observed for misonidazole plus cysteine. The protective effects of glutathione and thiourea were diminished by the addition of misonidazole. Results obtained for DNA single-strand breaks were similar to those for colony-forming ability. Experimental and clinical studies of radioprotective and radiosensitizing drugs were conducted to improve the cure rate of tumors. It is preferable that the protective agents selectively protect normal aerobic tissues, while the sensitizing agents selectively sensitize hypoxic tumor cells1-5).
日本放射線影響学会の論文