Efficiencies of DNA Inactivation and Mutation Induction by Tritiated glycerol in Bacterial Systems

概要

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When spores of Bccillus subtilis were treated in a frozen state with tritiated glycerol of different concentrations (up to 160 μCi/ml), efficiencies of killing and mutation induction per absorption dose were higher in solutions of lower tritium concentrations where low dose-rate β-irradiations were performed. Similarly when transforming DNA of Bacillus subtilis was kept with tritiated glycerol solution of concentrations ranging 0.05-500 μCi/ml at 4℃, efficiency of inactivation of the arginine marker increased strikingly by lowering the tritium concentration. On the other hand, the RBE of DNA-strand scissions of colicin El plasmids exposed to tritiated glycerol of a relatively high concentration (680 μCi/ml) was found to be approximately 1, when compared at the same absorption dose of gamma-irradiation (36 kR/hr) from a ^<137>Cs source.
日本放射線影響学会の論文