Studies on the Metabolism of Some Chemical Species of Radioruthenium in the Rat I. Early Fate of Ingested Ruthenium
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概要
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The whole body retention of three chemical species of ^<106>Ru was studied in rats. Three ruthenium species were ruthenium chioro complex (Ru-chloro), nitrosyl ruthenium nitrato complex (RuNO-nitrato) and nitrosyl ruthenium nitro complex (RuNO-nitro). When the compounds were administered orally, RuNO-nitro complex showed the highest retention, while RuNO-nitrato and Ru-chloro complexes demonstrated a comparablly low retention. The cumulative urinary excretion for three days of RuNO-nitro complex was the highest. The excretion of RuNO-nitrato was slightly but significantly higher than that of Ru-chloro complex. When the compounds were injected intravenously, the whole body retention of Ru-chloro complex was the highest, followed by RuNO-nitrato and RuNO-nitro in this order. These results suggest (1) that RuNO-nitro complex was absorbed more readily through gastrointestinal wall to the body than RuNO-nitrato and Ru-chloro and (2) that RuNO-nitro and -nitrato complexes in the body were metabolized and excreted faster than Ru-chloro complex.
- 日本放射線影響学会の論文
著者
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渡利 一夫
放射線医学総合研究所
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榎本 好和
放射線医学総合研究所環境衛生研究部
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市川 龍資
放射線医学総合研究所環境衛生研究部
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市川 龍資
National Institute of radiological Sciences
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榎本 好和
放射線医学総合研究所環境衛生研究部:(現)宮崎大学農学部家畜薬理学教室
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市川 龍資
放射線医学総合研究所
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