Comparative Studies of ^<132>Cs and ^<86>Rb Turn-over in Man using a Double-tracer Method

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Comparative studies of Cs and Rb metabolism were made with an adult male of human subject using ^<132>Cs and ^<86>Rb double-tracer method. Whole body retention and distribution after single oral administration were investigated by a whole body counter-scanner at the National Institute of Radiological Sciences, and total excreta in urine and feces that were collected for 9 days after the administration were measured separately by the same detector. Marked differences were found in the biological half-lives, excretion patterns and distributions in the whole body between the two radionuclides. Whole body retention could be expressed by two-component exponential function of time for the both nuclides, but short-term component had a shorter half-life (1.0 day) for ^<132>Cs than that for ^<86>Rb (6.0 days) and long-term component had a longer-life (72 days) for ^<132>Cs than that for ^<86>Rb (53 days). Total excretion of ^<132>Cs for the first 5 days after the administration was correspondingly larger than that of ^<86>Rb, but fecal excretion of ^<86>Rb was slightly larger than that of ^<132>Cs which resulted in a large disagreement in values of urinary-to-fecal excretion ratio between the two. Whole body distributions obtained with the elapse of time since the administration indicated that ^<86>Rb was transferred to its final compartments within 3 days, but ^<132>Cs needed more than 10 days. At the equilibrium in distribution ^<132>Cs concentrated in muscular tissues more specifically than did 86Rb, but 86Rb was present more in liver, heart, and brain etc., than ^<132>Cs. These results suggest that Cs must have a different metabolic pathway to that of Rb, and that effective elimination of ^<137>Cs from the human body can be made by some means when applied before 3 days after accidental ^<137>Cs intake.
日本放射線影響学会の論文

Comparative Studies of ^<132>Cs and ^<86>Rb Turn-over in Man using a Double-tracer Method

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