Effect of X-irradiation on Myosin-ATPase in the Presence of Histidine

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Effect of X-irradiation on myosin-ATPase has been studied. It was found that on X-irradiation, ATPase activity of myosin was markedly increased, if a certain amount of histidine was present in the solution. It was also found that when an aqueous solution of histidine was first irradiated with X-rays and then this irradiated histidine added to a myosin solution, an equally marked activation of myosin ATPase was produced. These results seem to indicate that some kinds of activating agent for myosin-ATPase was formed from histidine on irradiation. Irradiated histamine and imidazol were also found to be effective in producing a marked activation of ATPase when these were added to myosin solutions. However, when myosin solutions that contained either histamine or imidazol were irradiated, ATPase activity of these solutions was not so high as that observed when a myosin solution, containing histidine, were irradiated. Possible mechanisms involved in the activation of myosin-ATPase by X-irradiation in the presence of histidine have been discussed.
日本放射線影響学会の論文