Lysosomal Enzymes and Dibutyryl 3',5'-Adenosine Monophosphate Basic and Clinical Studies on Lysosomal Enzyme Activities in Glioma Tissues and Glial Cells
スポンサーリンク
概要
- 論文の詳細を見る
It is a well-known fact that damage to a cell induces activation of lysosomes. This phenomenon subsequently leads to "autofagy" and "heterofagy," which are typical functions of lysosomal enzymes. Some reports state that lysosomal enzymes are highly activated also during cellular division and multiplication. Furthermore, it has been verified that the enzymes retain by far a higher activity in malignant tumor cells. A recent report indicated that cyclic AMP supports morphologically cultured glial cells and glioma tissues toward their differentiation and further toward normalization. Based on these reports, it was the object of this study to examine the effect of cyclic AMP on lysosomal enzyme activities during cellular multiplication. In the acute stage, within one week from injury infliction, β-glucuronidase and acid-phosphatase increased activities conspicuously and reached their respective peaks on the 5th day after injury. The glial cell, being induced by the high enzyme activity, showed active cellular division and multiplication starting from the 5th day on. Although elevation of activity was clearly observed at this stage, the enzyme activity showed little difference during the period of gliosis formation, when division and multiplication settled. Human glioma tissues retained a level of activity several times higher. Administration of dibu-tyryl cyclic AMP in situ produced significant inhibitory tendency on the enzyme activity, resulting in impediment of multiplication. The rise in enzyme activity after cellular damage and along with cellular division were directly reflected in the cerebrospinal fluid, which might be utilized in diagnosing the extent of in-tracranial disorders, effectiveness of treatment and prognosis.
- 社団法人日本脳神経外科学会の論文
著者
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Shibata Iekado
Department Of Neurosurgery Toho University School Of Medicine
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SEIKI Yoshikatsu
Department of Neurosurgery, Toho University, Omori Medical Center
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YOSHII Nobuo
Department of Surgery, Keio University
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Sato Katsuyuki
Department Of Neurosurgery School Of Medicine Toho University
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Sato Katsuyuki
Department Of Medicine Tokyo Women's Medical University
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Fukuda Sakae
Shizuoka Red Cross Hosp.
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Fukuda Sakae
Shizuoka Red Cross Hospital
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Yoshii Nobuo
Department Of Neurosurgery Keio University
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Yoshii Nobuo
Department Of Neurosurgery School Of Medicine Toho University
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Yamada Fumito
Shizuoka Red Cross Hospital
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Takasu Nobuyoshi
Department Of Neurosurgery School Of Medicine Toho University
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MATSUMOTO Mikio
Department of Neurosurgery, School of Medicine, Toho University
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NAGASAWA Sadatsugu
Department of Neurosurgery, School of Medicine, Toho University
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Shibata Iekado
Departmert Of Neurosurhery School Of Meicine Toho University
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Shibata Iekado
2ed Department Of Surgery School Of Mdicine Toho University
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Seiki Yoshikatsu
Department Of Neurosurgery Toho University Omori Medical Center
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Matsumoto Mikiro
Department Of Neurosurgery Toho University School Of Medicine
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Takasu Nobumitsu
Departmert Of Neurosurhery School Of Meicine Toho University
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Nagasawa Sadatsug
Departmert Of Neurosurhery School Of Meicine Toho University
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Nagasawa Sadatsugu
Department Of Neurosurgery Toho University School Of Medicine
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Takasu Nobuyoshi
Department Of Neurosurgery Sakura Hospital Toho University School Of Medicine
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Seiki Yoshikatsu
Department Of Critical Care Center Toho University Medical Center Omori Hospital
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Shibata Iekado
Department Of Neurosurgery Ofuna Chuo Hospital
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SEIKI Yoshikatsu
Department of Neurosurgery,Toho University School of Medicine
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Sato Katsuyuki
Department of Applied Chemistry, Faculty of Engineering, Iwate University
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