Biochemical Changes in Experimental Rat Brain Tumros Induced by Ethylnitrosourea and Human Gliomas after Dibutyryl Cyclic AMP Treatment
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概要
- 論文の詳細を見る
Previous reports have shown that dibutyryl 3′, 5′adenosine monophosphate (DBc -AMP) suppresses growth of actively dividing tumor cells, accelerates normalization of cellular metabolism and elevates the intracellular level of cyclic AMP. In an effort to study this mechanism further and define its significance, studies were performed on pregnant rats with ethylnitrosourea (ENU) induced gliomas and human subjects with malignant gliomas. RNA and DNA were detected in remarkably high concentrations in the tumor tissue with a significant reduction after treatment with DBc -AMP. The reduction was more pronounced with RNA. Free amino acids were noted in relatively low concentrations in tumor tissue. However, treatment with DBc -AMP resulted in a significant elevation of their value. The levels of glutamic acid, aspartic acid and GABA increased to levels corresponding to the composition of free amino acids in normal brain tissues. Lysosomal enzyme activity in tumor tissue was 10 times greater than that in normal brain tissue. This activity dropped significantly after administration of DBc -AMP. In rats with ENU induced glioma, the uptake of radiocative [H^3] DBc -AMP by tumor tissue occurred in a volume 2-3 times that of normal tissue. However, the ratio of [H^3] cyclic AMP/cyclic AMP was less than that in normal tissue, implying that an enhanced synthesis of endogenous cyclic AMP occurs after administration of DBc -AMP.
- 日本脳神経外科学会の論文
- 1982-01-15
著者
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Shibata Iekado
Department Of Neurosurgery Toho University School Of Medicine
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Shibata Iekado
Departmert Of Neurosurhery School Of Meicine Toho University
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Shibata Iekado
2ed Department Of Surgery School Of Mdicine Toho University
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Seiki Yoshikatsu
Department Of Neurosurgery Toho University Omori Medical Center
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Matsumoto Mikiro
Department Of Neurosurgery Toho University School Of Medicine
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Nagasawa Sadatsug
Departmert Of Neurosurhery School Of Meicine Toho University
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Nagasawa Sadatsugu
Department Of Neurosurgery Toho University School Of Medicine
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TAKEZAWA Junichi
Research Laboratory,Yamasa Yhoyu Company Co Ltd
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Takezawa Junichi
Research Laboratory Yamasa Yhoyu Company Co Ltd
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Seiki Yoshikatsu
Department Of Critical Care Center Toho University Medical Center Omori Hospital
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Shibata Iekado
Department Of Neurosurgery Ofuna Chuo Hospital
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SEIKI Yoshikatsu
Department of Neurosurgery,Toho University School of Medicine
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