Pharmacokinetic Study of Selective Continuous Internal Carotid CDDP Infusion in Malignant Brain Tumors
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概要
- 論文の詳細を見る
Cis-diamminedichloroplatinum (CDDP) was administered by selective continuous internal carotid infusion to nine patients with malignant brain tumors, including five glioblastomas, one mixed glioma, and three metastatic tumors. CDDP was infused through a catheter in the internal carotid artery at 100 mg/hr in all cases, except one glioblastoma case in which the lower rate of 10 mg/hr was used. The results of CDDP concentration measurements were: 1) CDDP in the blood peaked at termination of CDDP infusion and then decreased slowly, 2) CDDP infiltrated intratumoral cysts and accumulated there, 3) CDDP in the cerebrospinal fluid peaked 6-18 hours after infusion, and 4) the tumor/plasma CDDP ratio varied from 2 to 8. The size of tumors decreased moderately in three of the nine cases, but no complete response was achieved. The histological changes due to CDDP were observed in the tumor tissue and were absent in the normal brain parenchyma.
- 日本脳神経外科学会の論文
- 1991-11-15
著者
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Terao Hideo
Department Of Neurosurgery Toho University School Of Medicine
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Terao Hideo
Department Of Agricultural Engineering Faculty Of Agriculture Hokkaido University
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Shibata Iekado
Department Of Neurosurgery Toho University School Of Medicine
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Kudo Motoshige
Department Of Pathology School Of Medicine Toho University
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Kudo Motoshige
Department Of Pathology Toho University School Of Medicine
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Noguchi Tetsuya
Department Of Physiology Toho University School Of Medicine
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Noguchi Tetsuya
Department Of Gastroenterology Miyagi Cancer Center
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Seiki Yoshikatsu
Department Of Neurosurgery Toho University Omori Medical Center
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Seiki Yoshikatsu
Department Of Neurosurgery Toho University School Of Medicine
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Seiki Yoshikatsu
Department Of Critical Care Center Toho University Medical Center Omori Hospital
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Shibata Iekado
Department Of Neurosurgery Ofuna Chuo Hospital
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SHIBATA Iekado
Department of Neurosurgery, Toho University School of Medicine
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