頭蓋内圧亢進と睡眠について : 実験的plateau waveの作成

概要

論文の詳細を見る
Plateau waves were produced experimentally during evoked sleep in cats and primates with kaolin-induced hydrocephalus. At the acute stage of hydrocephaltas with moderate irntracranial hypertention, Krebs-Ringer's solution containing excess calcium was perfused within the posterior region of the hypothalamus to induce sleep. Behavioral and physiological signs such as sleep were evoked within 5 to 30 min. following the start of perfusion, and lasted as long as 3 to 5 hours. When calcium ions had not sufficiently altered the arousal level of animals, sleep was induced by intravenous administration of a precursor of serotonin. In cats and primates with ICP raised above 15 mmHg, the ICP during induced sleep was exaggerated and developed plateau waves which had amplitudes of over 90 mmHg and durations of within 5 min. These platcatr waves were highly reproducible. A relatively right situation of the intracranial space was a necessary condition for production of the plateau waves. The functional change in the hypothalamus involved in the sleep mechanism plays as an important role in formation of the plateau waves.
日本脳神経外科学会の論文
1980-12-15